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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE5A
All Species:
11.52
Human Site:
S86
Identified Species:
19.49
UniProt:
O76074
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O76074
NP_001074.2
875
100013
S86
C
S
C
P
L
Q
Q
S
P
R
A
D
N
S
V
Chimpanzee
Pan troglodytes
XP_001150967
875
99910
S86
C
S
C
P
L
Q
Q
S
P
R
A
D
N
S
A
Rhesus Macaque
Macaca mulatta
XP_001099652
875
100002
S86
C
S
C
P
L
Q
Q
S
P
R
A
D
N
S
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG03
865
98403
A88
N
T
T
P
G
A
P
A
R
K
I
S
A
S
E
Rat
Rattus norvegicus
O54735
833
94538
S86
T
V
S
F
L
S
D
S
G
K
K
E
Q
M
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512580
863
98139
R88
T
A
H
G
T
P
V
R
K
I
S
A
S
E
F
Chicken
Gallus gallus
P52731
862
99990
I79
E
A
G
S
M
E
K
I
V
H
K
T
L
Q
R
Frog
Xenopus laevis
NP_001088271
859
97399
V80
N
T
T
Q
G
T
P
V
R
K
I
S
A
S
E
Zebra Danio
Brachydanio rerio
XP_001923466
856
97075
T84
S
P
A
P
S
T
P
T
R
K
I
S
A
S
E
Tiger Blowfish
Takifugu rubipres
Q1KKS3
903
102001
E97
N
V
N
R
T
Y
D
E
H
V
N
S
R
A
Q
Fruit Fly
Dros. melanogaster
Q9VJ79
1451
160911
S341
H
L
H
H
S
Q
H
S
H
Y
Q
A
G
G
A
Honey Bee
Apis mellifera
XP_394107
1016
115998
A121
Q
G
M
A
V
V
Q
A
K
S
P
L
K
N
I
Nematode Worm
Caenorhab. elegans
P91119
710
81117
K15
K
Y
L
Q
E
N
P
K
L
V
E
D
F
V
V
Sea Urchin
Strong. purpuratus
NP_001029121
949
108476
L93
G
T
K
S
L
R
N
L
L
S
P
R
R
R
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
N.A.
N.A.
92.4
88.9
N.A.
87.8
25.1
75.1
71.1
38.1
31.2
37.5
26.6
39
Protein Similarity:
100
99.7
99.4
N.A.
N.A.
94.5
91
N.A.
91.6
44.2
85
83.1
58.1
41.3
54.6
44.2
55.9
P-Site Identity:
100
93.3
93.3
N.A.
N.A.
13.3
13.3
N.A.
0
0
6.6
13.3
0
13.3
6.6
13.3
6.6
P-Site Similarity:
100
93.3
93.3
N.A.
N.A.
33.3
26.6
N.A.
20
26.6
20
26.6
6.6
13.3
33.3
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
8
8
0
8
0
15
0
0
22
15
22
8
22
% A
% Cys:
22
0
22
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
15
0
0
0
0
29
0
0
0
% D
% Glu:
8
0
0
0
8
8
0
8
0
0
8
8
0
8
22
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
8
% F
% Gly:
8
8
8
8
15
0
0
0
8
0
0
0
8
8
0
% G
% His:
8
0
15
8
0
0
8
0
15
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
0
8
22
0
0
0
8
% I
% Lys:
8
0
8
0
0
0
8
8
15
29
15
0
8
0
8
% K
% Leu:
0
8
8
0
36
0
0
8
15
0
0
8
8
0
0
% L
% Met:
0
0
8
0
8
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
22
0
8
0
0
8
8
0
0
0
8
0
22
8
0
% N
% Pro:
0
8
0
36
0
8
29
0
22
0
15
0
0
0
8
% P
% Gln:
8
0
0
15
0
29
29
0
0
0
8
0
8
8
8
% Q
% Arg:
0
0
0
8
0
8
0
8
22
22
0
8
15
8
8
% R
% Ser:
8
22
8
15
15
8
0
36
0
15
8
29
8
43
0
% S
% Thr:
15
22
15
0
15
15
0
8
0
0
0
8
0
0
0
% T
% Val:
0
15
0
0
8
8
8
8
8
15
0
0
0
8
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
8
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _